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Prostate cancer screening is the screening process used to detect undiagnosed prostate cancer in men without signs or symptoms. [1][2] When abnormal prostate tissue or cancer is found early, it may be easier to treat and cure, but it is unclear if early detection reduces mortality rates. [2] Screening precedes a diagnosis and subsequent treatment.
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein -related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
Most medical guidelines recommend that men at high risk of prostate cancer (due to age, family history, ethnicity, or prior evidence of high blood PSA levels) be counseled on the risks and benefits of PSA testing, and be offered access to screening tests. [12] Medical guidelines generally recommend against screening for men over age 70, or with ...
If there are warning signs of prostate cancer, they can include: Blood in the urine or semen. Problems urinating—including feeling like you need to urinate more often or a slow or weak stream ...
The United States Preventive Services Task Force (USPSTF) is "an independent panel of experts in primary care and prevention that systematically reviews the evidence of effectiveness and develops recommendations for clinical preventive services". [1] The task force, a volunteer panel of primary care clinicians (including those from internal ...
In 1994, the Food and Drug Administration approved the use of measurements of the prostate specific antigen (PSA) to be used as part of a screening test for prostate cancer. That changed a decade ...
94 million men affected globally (2019) [ 3 ] Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. [ 1 ] Symptoms may include frequent urination, trouble starting to urinate, weak stream, inability to urinate, or loss of bladder control. [ 1 ]
It causes a dramatic reduction in PSA levels and tumor sizes in aggressive advanced-stage prostate cancer for 70% of patients. [47] [48] Chemotherapy may be offered to slow disease progression and postpone symptoms. The most commonly used regimen combines the chemotherapeutic drug docetaxel with a corticosteroid such as prednisone.
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