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In 2022, the combination of ethinylestradiol with norethisterone or with norethisterone acetate was the 80th most commonly prescribed medication in the United States, with more than 8 million prescriptions. [5] [6] It is available as a generic medication. [7]
Norethisterone and ethinylestradiol levels over 24 hours after a single oral dose of 10 mg NETA in postmenopausal women. [25] NETA metabolizes into ethinylestradiol at a rate of 0.20 to 0.33% across a dose range of 10 to 40 mg. [26] [27] Peak levels of ethinylestradiol with a 10, 20, or 40 mg dose of NETA were 58, 178, and 231 pg/mL, respectively.
Norethisterone is a substrate for and is known to be an inhibitor of 5α-reductase, with 4.4% and 20.1% inhibition at 0.1 and 1 μM, respectively. [11] However, therapeutic concentrations of norethisterone are in the low nanomolar range, so this action may not be clinically relevant at typical dosages.
Many over-the-counter products, despite a label indicating they are safe for cats, can cause toxic reactions in some cats," says Dr. Erin Katribe, medical director at Best Friends Animal Society.
On July 13, the FDA did approve the progestin-only Opill brand for over-the-counter use, which is a step in the right direction. The post Free the Meds: 5 Drugs You Should Be Able To Buy Over the ...
[7] [4] Norgestrel is available as a generic medication. [13] In 2022, the version with ethinylestradiol was the 264th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [14] [15] In July 2023, the US Food and Drug Administration (FDA) approved norgestrel for over-the-counter sale. [2]
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