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Research conducted in the 1920s and 1930s led to the first detailed pathologic descriptions of lupus and demonstrated how the disease affected the kidney, heart, and lung tissue. [165] A breakthrough was made in 1948 with the discovery of the LE cell (the lupus erythematosus cell—a misnomer, as it occurs with other diseases as well).
An estimated 5 million people worldwide have some form of lupus disease. [23] 70% of lupus cases diagnosed are systemic lupus erythematosus. [23] 20% of people with lupus will have a parent or sibling who already has lupus or may develop lupus. [23] about 5% of the children born to individuals with lupus will develop the illness. [23]
Scientists have long suspected that a person’s genetics or hormones may predispose them to lupus, and that the disease may be triggered by environmental factors like a previous viral infection ...
Levels of DNMT1 is partly regulated by the ERK signaling pathway in the body. In patients with SLE, ERK activity has been found to be reduced in lupus CD4+ T-cells. When ERK activity is suppressed, it causes there to be a reduction in DNMT1 expression and DNA hypomethylation levels increases.
Childhood-onset systemic lupus erythematosus (i.e., cSLE), also termed juvenile-onset systemic lupus erythematosus, juvenile systemic lupus erythematosus, and pediatric systemic lupus erythematosus, is a form of the chronic inflammatory and autoimmune disease, systemic lupus erythematosus (i.e., SLE), that develops in individuals up to 18 years old. [1]
What it looks like: Lupus, a chronic autoimmune disease that causes inflammation throughout the body, often presents with a red, butterfly-shaped rash across the cheeks and nose. It is usually ...
In 2022, Halsey was diagnosed with lupus SLE, a chronic disease where the body’s immune system attacks its own tissues and organs. It can damage many parts of the body, including the joints ...
A familial tendency to develop autoimmune diseases suggests a genetic component. Some conditions, like lupus and multiple sclerosis, often occur in several members of the same family, indicating a potential hereditary link. Additionally, certain genes have been identified that increase the risk of developing specific autoimmune diseases.