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Acarbose is an oligosaccharide, whereas miglitol resembles a monosaccharide. Miglitol is fairly well absorbed by the body, as opposed to acarbose. Moreover, acarbose inhibits pancreatic alpha-amylase in addition to alpha-glucosidase, and is degraded by gut bacterial maltogenic alpha-amylase and cyclomaltodextrinase. [4] [5]
Miglitol is an oral alpha-glucosidase inhibitor used in the treatment of type 2 diabetes. It works by reversibly inhibiting alpha-glucosidase enzymes in the small intestine, which delays the digestion of complex carbohydrates and subsequently reduces postprandial glucose levels. [ 1 ]
Hence, α-glucosidase inhibitors (like acarbose) are used as anti-diabetic drugs in combination with other anti-diabetic drugs. Luteolin has been found to be a strong inhibitor of α-glucosidase. The compound can inhibit the enzyme up to 36% with a concentration of 0.5 mg/ml. [ 21 ] As of 2016, this substance is being tested in rats, mice and ...
Acarbose degradation is the unique feature of glycoside hydrolases in gut microbiota, acarbose degrading glucosidase, which hydrolyze acarbose into an acarviosine-glucose and glucose. [17] Human enzymes do transform acarbose: the pancreatic alpha-amylase is able to perform a rearrangement reaction , moving the glucose unit in the "tail" maltose ...
D-xylose absorption test is a medical test performed to diagnose conditions that present with malabsorption of the proximal small intestine [1] due to defects in the integrity of the gastrointestinal mucosa. [2] D-xylose is a monosaccharide, or simple sugar, that does not require enzymes for digestion prior to absorption. Its absorption ...
Alpha-glucosidase inhibitors (acarbose, miglitol, voglibose) Inhibit carbohydrate digestion in the small intestine by inhibiting enzymes that break down polysaccharides Slightly lower risk of hypoglycemia compared to sulfonylureas; Associated with modest weight loss; Decreases triglycerides; No detrimental effect on cholesterol
The L.A. band Dawes, whose members were seriously impacted by the Eaton fire, on what it meant to perform Newman's early-'80s classic.
Alpha glucosidase inhibitors delay glucose absorption at the intestine level and thereby prevent sudden surge of glucose after a meal. [ 2 ] There are three major drugs which belong to this class, acarbose , miglitol and voglibose, [ 2 ] of which voglibose is the newest.