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Lactic acidosis refers to the process leading to the production of lactate by anaerobic metabolism. It increases hydrogen ion concentration tending to the state of acidemia or low pH. The result can be detected with high levels of lactate and low levels of bicarbonate. This is usually considered the result of illness but also results from ...
There is no proven treatment for congenital lactic acidosis. Treatments that are occasionally used or that are under investigation include the ketogenic diet and dichloroacetate. Other treatments aim to relieve symptoms – for example, anticonvulsants may be used to relieve seizures. [1]
Treatment Intravenous fluids/ high dextrose concentration [ 5 ] Short-chain acyl-coenzyme A dehydrogenase deficiency (SCADD) is an autosomal recessive [ 6 ] fatty acid oxidation disorder which affects enzymes required to break down a certain group of fats called short chain fatty acids .
Lactate dehydrogenase A catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD +. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumors, and belongs to the lactate dehydrogenase family. It has long been known that many human cancers have higher LDHA levels ...
Reaction catalyzed by lactate dehydrogenase. Lactate dehydrogenase catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD +.It converts pyruvate, the final product of glycolysis, to lactate when oxygen is absent or in short supply, and it performs the reverse reaction during the Cori cycle in the liver.
Side effects may include allergic reactions, high blood potassium, hypervolemia, and high blood calcium. [2] It may not be suitable for mixing with certain medications and some recommend against use in the same infusion as a blood transfusion. [4] Ringer's lactate solution has a lower rate of acidosis as compared with normal saline.
Anti-hypertensives are blood pressure medications used to treat high blood pressure in pregnant women. [38] This class of medication is commonly used to treat problems such as heart failure, heart attack, and kidney failure. [38] Caution must be exercised with the use of various hypertensive agents for the treatment of blood pressure. [57]
Mutations in the HADHA gene lead to inadequate levels of an enzyme called long-chain 3-hydroxyacyl-coenzyme A dehydrogenase, which is part of a protein complex known as mitochondrial trifunctional protein. Long-chain fatty acids from food and body fat cannot be metabolized and processed without sufficient levels of this enzyme.