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Permissive hypotension or hypotensive resuscitation [1] is the use of restrictive fluid therapy, specifically in the trauma patient, that increases systemic blood pressure without reaching normotension (normal blood pressures).
An antihypotensive, also known as vasopressor, is an agent that raises blood pressure by constricting blood vessels, thereby increasing systemic vascular resistance. This is different from inotropes which increase the force of cardiac contraction. Some substances do both (e.g. dopamine, dobutamine).
551 11998 Ensembl ENSG00000101200 ENSMUSG00000037727 UniProt P01185 P35455 RefSeq (mRNA) NM_000490 NM_009732 RefSeq (protein) NP_000481 NP_033862 Location (UCSC) Chr 20: 3.08 – 3.08 Mb Chr 2: 130.42 – 130.42 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized ...
This internalized G s signaling by V 2 R is explained by the receptors ability to form "mega-complexes" consisting of a single V 2 R, β-arrestin, and heterotrimeric G s. [3] The increased intracellular cAMP in the kidney in turn triggers fusion of aquaporin-2 -bearing vesicles with the apical plasma membrane of the collecting duct principal ...
Vasopressin (antidiuretic hormone, ADH) is another vasopressor often used in combination with norepinephrine [10] Certain vasopressors ( ephedrine , norepinephrine ). Norepinephrine (Levophed) is the most common first-line vasopressor for people who don't respond well to other hypotension treatments such as fluid resuscitation.
EMCrit is an American medical collective and publishing group made up of physicians in the field of critical care and emergency medicine. [ 1 ] [ 2 ] The group publishes a number of digital resources to equip physicians, clinical pharmacists, nurses , paramedics and researchers .
Midodrine is a prodrug which forms the active metabolite, desglymidodrine, which is an α 1-adrenergic receptor agonist and exerts its actions via activation of α 1-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure.