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The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.
A new study suggests the vaccine could help stop cancerous cells returning. HPV jab ‘may ward off cervical cancer in women with pre-cancerous cells’ Skip to main content
There is high-certainty evidence that HPV vaccines protect against precancerous cervical lesions in young women, particularly those vaccinated aged 15 to 26. [158] HPV vaccines do not increase the risk of serious adverse events. [158] Longer follow-up is needed to monitor the impact of HPV vaccines on cervical cancer. [158]
Cervical intraepithelial neoplasia (CIN) means the development of abnormal cells on the surface of the cervix. It is caused by an HPV infection but in most cases, it is resolved by the immune system. However, a small percentage of people might develop a more serious CIN which, if left untreated, can develop into cervical cancer.
Currently, the pap smear — in which cells taken from the cervix are examined by a doctor “for cervical cancer or cell changes,” per the National Cancer Institute — is the recommended ...
The Papanicolaou test (abbreviated as Pap test, also known as Pap smear (AE), [1] cervical smear (BE), cervical screening (BE), [2] or smear test (BE)) is a method of cervical screening used to detect potentially precancerous and cancerous processes in the cervix (opening of the uterus or womb) or, more rarely, anus (in both men and women). [3]
A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk of developing into cancer. [ 1 ] [ 2 ] [ 3 ] Clinically, precancerous conditions encompass a variety of abnormal tissues with an increased risk of developing into cancer.
ThinPrep pap smear with group of normal cervical cells on left and HPV-infected cells showing features typical of koilocytes: enlarged (x2 or x3) nuclei and hyperchromasia. A koilocyte is a squamous epithelial cell that has undergone a number of structural changes, which occur as a result of infection of the cell by human papillomavirus (HPV). [1]
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