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A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of PDE inhibitors. The PDE4 family of enzymes are the most prevalent PDE in immune cells. They are predominantly ...
Roflumilast, sold under the brand name Daxas among others, is a medication used for the treatment of chronic obstructive pulmonary disease, [4] plaque psoriasis, [5] seborrheic dermatitis, [6] and atopic dermatitis. [5] It acts as a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). [10] It has anti-inflammatory effects ...
Adibendan; Aminophylline; Aminophylline dihydrate; Amipizone; Apremilast; Arofylline; Atizoram; Befuraline; Bemarinone hydrochloride; Bemoradan; Benafentrine; Bucladesine
It inhibits PDE4 to the greatest extent, but also shows significant inhibition of other PDE subtypes, and so acts as a selective PDE4 inhibitor or a non-selective phosphodiesterase inhibitor, depending on the dose. Piclamilast, a more potent inhibitor than rolipram. [25] Luteolin, supplement extracted from peanuts that also possesses IGF-1 ...
It showed reasonable efficacy for treating COPD, but side effects were problematic and it is unclear whether cilomilast will be marketed, or merely used in the development of newer drugs. [ 3 ] [ 4 ] Cilomilast is a second-generation PDE4 inhibitor with anti-inflammatory effects that target bronchoconstriction , mucus hypersecretion, and airway ...
Rolipram continues to be used in research as a well-characterized PDE4 inhibitor. [3]: 669 It has been used in studies to understand whether PDE4 inhibition could be useful in autoimmune diseases, [5] Alzheimer's disease, [6] cognitive enhancement, [7] spinal cord injury, [8] and respiratory diseases like asthma and COPD. [9]
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