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Invasion of tumours through the layers of the gastrointestinal wall is used in staging of tumour spread. This affects treatment and prognosis. The normal thickness of the small intestinal wall is 3–5 mm, [6] and 1–5 mm in the large intestine. [7] Focal, irregular and asymmetrical gastrointestinal wall thickening suggests a malignancy. [7]
The ethmoid air cells consist of numerous thin-walled cavities in the ethmoidal labyrinth [4] that represent invaginations of the mucous membrane of the nasal wall into the ethmoid bone. [3] They are situated between the superior parts of the nasal cavities and the orbits, and are separated from these cavities by thin bony lamellae. [4]
The intestinal epithelium is the single cell layer that forms the luminal surface (lining) of both the small and large intestine (colon) of the gastrointestinal tract.Composed of simple columnar epithelium its main functions are absorption, and secretion.
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The length of the human colon is, on average 160.5 cm (measured from the bottom of the cecum to the colorectal junction) with a range of 80 cm to 313 cm. [11] The average inner circumference of the colon is 6.2 cm. [10] Thus, the inner surface epithelial area of the human colon has an area, on average, of about 995 cm 2, which includes ...
Promotes goblet cell differentiation in colon: 21070761 [35] 12015290 [36] LGR4: GPR48: Promotes Paneth cell differentiation and crypt cell proliferation. Along with LGR5, acts as the receptor for R-Spondin, a WNT co-ligand that amplifies WNT signaling: 21508962 [37] 21909076 [38] LGR5: GPR49: Premature paneth cell differentiation in fetal ...
Intestinal stem cell aging has been studied in Drosophila as a model for understanding the biology of stem cell/niche aging. [4] Using knockdown mutants defective in various genes that function in the DNA damage response in enterocytes, it was shown that deficiency in the DNA damage response accelerates intestinal stem cell aging, thus ...
Simple columnar epithelium is a single layer of columnar epithelial cells which are tall and slender with oval-shaped nuclei located in the basal region, attached to the basement membrane. In humans, simple columnar epithelium lines most organs of the digestive tract including the stomach , and intestines .