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Malignant hyperthermia is diagnosed on clinical grounds, but various laboratory investigations may prove confirmatory. These include a raised creatine kinase level, elevated potassium, increased phosphate (leading to decreased calcium) and—if determined—raised myoglobin; this is the result of damage to muscle cells.
Neuroleptic malignant syndrome; rare, life-threatening hyperpyrexia caused by antidopaminergic drugs (mostly antipsychotics) e.g. Haloperidol, Chlorpromazine Serotonin syndrome ; excessive serotonergic activity due usually to combined use of serotonergic drugs ( e.g. antidepressants , stimulants , triptans )
A common cause of hyperpyrexia is an intracranial hemorrhage. [7] Other causes in emergency room settings include Malignant Catatonia, sepsis, Kawasaki syndrome, [62] neuroleptic malignant syndrome, drug overdose, serotonin syndrome, and thyroid storm. [61]
Malignant hyperthermia is a rare complication of some types of general ... Different sources have different cut-offs for fever, hyperthermia and hyperpyrexia.
Intracerebral B-cell lymphoma represents less than 1% of all primary malignant tumors of the central nervous system. [ 6 ] [ 1 ] [ 3 ] Infiltration of lymphoma cells into the pons and medulla is the most frequently reported cause of CNH, accounting for half of all CNH-inducing brain tumors, despite its considerable rarity.
The urgency and medical severity of the condition needs to be given impetus in terms of handling patients with Bell's Mania. Due to the homologous nature of this syndrome with malignant hyperthermia (MH) and neuroleptic malignant syndrome (NMS), [31] Dantrolene [32] is also a probable treatment route owing to its swift acidosis correction ...
Antipsychotic medications may cause neuroleptic malignant syndrome, which can cause severe muscle rigidity with rhabdomyolysis and hyperpyrexia; Neuromuscular blocking agents used in anesthesia may result in malignant hyperthermia, also associated with rhabdomyolysis; Medications that cause serotonin syndrome, such as SSRIs
Central core disease has been found to be allelic with malignant hyperthermia, [11] which is a life-threatening anesthetic reaction that causes a rise in body temperature, muscular rigidity and muscular breakdown, grossly elevated creatine kinase, and acidosis.