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Anatomy Atlases – Microscopic Anatomy, plate 09.175 - "Spleen: Red Pulp" Histology image: 07803loa – Histology Learning System at Boston University - "Lymphoid Tissues and Organs: splenic reticulum"
The fibroelastic coat of the spleen invests the organ, and at the hilum is reflected inward upon the vessels in the form of sheaths. From these sheaths, as well as from the inner surface of the fibroelastic coat, numerous small fibrous bands, the trabeculae of the spleen (or splenic trabeculae), emerge from all directions; these uniting, constitute the frame-work of the spleen.
An easy way to remember the anatomy of the spleen is the 1×3×5×7×9×10×11 rule. The spleen is 1 by 3 by 5 inches (3 by 8 by 13 cm), weighs approximately 7 oz (200 g), and lies between the ninth and eleventh ribs on the left-hand side and along the axis of the tenth rib.
White pulp is a histological designation for regions of the spleen (named because it appears whiter than the surrounding red pulp on cross section), that encompasses approximately 25% of splenic tissue. White pulp consists entirely of lymphoid tissue. Specifically, the white pulp encompasses several areas with distinct functions:
Periarteriolar lymphoid sheaths (or periarterial lymphatic sheaths, or PALS) are a portion of the white pulp of the spleen.They are populated largely by T cells and surround central arteries within the spleen; the PALS T-cells are presented with blood borne antigens via myeloid dendritic cells.
White pulp, splenic lymphoid nodules, or white nodules — follicles in the white pulp of the spleen, containing many lymphocytes These structures are named after Marcello Malpighi (1628–1694), an Italian physician and biologist regarded as the father of microscopical anatomy and histology .
The red pulp of the spleen is composed of connective tissue known also as the cords of Billroth and many splenic sinusoids that are engorged with blood, giving it a red color. [ 1 ] [ 2 ] Its primary function is to filter the blood of antigens , microorganisms, and defective or worn-out red blood cells.
The trabecular arteries are the name of the branches of the splenic artery after it passes into the trabeculae of the spleen, where it branches.When these arteries then reach the white pulp, and become covered with periarteriolar lymphoid sheaths, the name changes again to central arteries (or central arterioles).
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