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Rituximab works by decreasing levels of B-cells (immune cell that is involved in inflammation). People taking rituximab had improved pain, function, reduced disease activity and reduced joint damage based on x-ray images. After 6 months, 21% more people had improvement in their symptoms using rituximab and methotrexate. [133]
Legg–Calvé–Perthes disease; Legius syndrome; Leiner's disease; Lelis syndrome; Lemierre's syndrome; Lennox–Gastaut syndrome; Lenz microphthalmia syndrome; Lenz–Majewski syndrome; Leriche's syndrome; Leschke syndrome; Lesch–Nyhan syndrome; Lethal congenital contracture syndrome; Lethal white syndrome
Gorham's disease (pronounced GOR-amz), also known as Gorham vanishing bone disease and phantom bone disease, [1] is a very rare skeletal condition of unknown cause.It is characterized by the uncontrolled proliferation of distended, thin-walled vascular or lymphatic channels within bone, which leads to resorption and replacement of bone with angiomas and/or fibrosis.
Joint pain is a common but non-specific sign of joint disease. Signs will depend on the specific disease, and may even then vary. Common signs may include: [citation needed] Decreased range of motion; Stiffness; Effusion; Pneumarthrosis, air in a joint (which is also a common normal finding). Bone erosion; Systemic signs of arthritis such as ...
Joint is derived from Latin iunctus, [21] past participle of the Latin verb iungere, join, unite, connect, attach. [22] The English term articulation is derived from Latin articulatio. [21] Humans have also developed lighter, more fragile joint bones over time due to the decrease in physical activity compared to thousands of years ago. [23]
It affects humans and other animals, notably dogs, but also occurs in cats and horses. It can affect both the larger (ie. knee, hip, shoulder, etc.) and the smaller joints (ie. fingers, toes, foot, etc.) of the body. The disease is caused by daily wear and tear of the joint. This process can progress more rapidly as a result of injury to the joint.
Inflammatory bowel disease about 400 Caucasians per 100,000 people, with a male–to–female ratio of 1:1. [ 59 ] [ 58 ] People of Asian and African ancestry rarely experience it. Varying reports have varying risks for spondylitis and peripheral arthritis, which may be related to the observer's specialty. 15% to 20% of people with inflammatory ...
Juvenile, in this context, refers to disease onset before 16 years of age, while idiopathic refers to a condition with no defined cause, and arthritis is inflammation within the joint. [4] JIA is an autoimmune, noninfective, inflammatory joint disease, the cause of which remains poorly understood. It is characterised by chronic joint inflammation.