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A corepressor downregulates (or represses) the expression of genes by binding to and activating a repressor transcription factor. The repressor in turn binds to a gene's operator sequence (segment of DNA to which a transcription factor binds to regulate gene expression), thereby blocking transcription of that gene.
In addition, compressors bind preferentially to the apo (ligand free) form of the nuclear receptor (or possibly antagonist bound receptor). CtBP 602618 SIN3A (associates with class II histone deacetylases) LCoR (ligand-dependent corepressor) Nuclear receptor CO-Repressor (NCOR) NCOR1
A co-repressor is a molecule that can bind to the repressor and make it bind to the operator tightly, which decreases transcription. A repressor that binds with a co-repressor is termed an aporepressor or inactive repressor. One type of aporepressor is the trp repressor, an important metabolic protein in bacteria.
KLFs are divided into three subgroups; Group 1 (KLF 3,8, and 12) are repressors via interaction with the C-terminal Binding Protein 1 and 2 (CtBP1 and CtBP2). Group 2 (KLFs 1,2,4,5,6, and 7) are transcription activators. Group 3 (KLFs 9,10,11,13,12, and 16) have repressor activity via interaction with the common transcriptional co-repressor ...
The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression.
The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene. [ 5 ] [ 6 ] NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains.
The repressilator is a genetic regulatory network consisting of at least one feedback loop with at least three genes, each expressing a protein that represses the next gene in the loop. [1]
The first authentic, common nuclear receptor coactivator was steroid receptor coactivator 1, or SRC-1 (NCOA1), first cloned in Bert O’Malley's laboratory. [8] SRC-1 and two related proteins, GRIP-1 (NCOA2), cloned first by Michael Stallcup, [ 9 ] and ACTR/p/CIP (NCOA3), initially identified in Ron Evans [ 10 ] and Geoff Rosenfeld's lab, [ 11 ...