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  2. Simvastatin - Wikipedia

    en.wikipedia.org/wiki/Simvastatin

    Simvastatin also reduced the numbers of other events like heart attacks, strokes, and revascularizations and MI significantly. [11] The Heart Protection Study evaluated the effects of simvastatin in people with risk factors including existing cardiovascular disease, diabetes, or stroke, but having relatively low LDL cholesterol. In this trial ...

  3. Statin - Wikipedia

    en.wikipedia.org/wiki/Statin

    Guidelines by the American College of Cardiology and the American Heart Association recommend statin treatment for primary prevention of cardiovascular disease in adults with LDL cholesterol ≥ 190 mg/dL (4.9 mmol/L) or those with diabetes, age 40–75 with LDL-C 70–190 mg/dL (1.8–4.9 mmol/dL); or in those with a 10-year risk of developing ...

  4. Ezetimibe/simvastatin - Wikipedia

    en.wikipedia.org/wiki/Ezetimibe/simvastatin

    Ezetimibe/simvastatin is a drug combination used for ... Side effects Myopathy ... randomized 18,144 patients with ACS to simvastatin 40 mg/d plus ezetimibe 10 mg/d ...

  5. Heart Protection Study - Wikipedia

    en.wikipedia.org/wiki/Heart_Protection_Study

    While there have been concerns about side-effects associated with statins (myopathy and rhabdomyolysis), these were rare in this study. [citation needed] The number needed to treat in the study was 57 to postpone one death and 19 to prevent one cardiovascular "event" (in those taking the drug simvastatin for 5 years). There was no mortality ...

  6. Ezetimibe - Wikipedia

    en.wikipedia.org/wiki/Ezetimibe

    Serious side effects may include anaphylaxis, liver problems, depression, and muscle breakdown. [4] [5] Use in pregnancy and breastfeeding is of unclear safety. [10] Ezetimibe works by decreasing cholesterol absorption in the intestines. [5] Ezetimibe was approved for medical use in the United States in 2002. [4] It is available as a generic ...

  7. Sitagliptin/simvastatin - Wikipedia

    en.wikipedia.org/wiki/Sitagliptin/simvastatin

    Sitagliptin: Using male and female rats, a two-year carcinogenicity study was carried out with doses of 50, 150, and 500 mg/kg/day. The 500 mg/kg dose has exposure limits of 60 times what would be seen in the highest dose in humans. At this dose, liver adenoma/carcinoma was seen. Tumors were not seen from the smaller doses.

  8. Fenofibrate/simvastatin - Wikipedia

    en.wikipedia.org/wiki/Fenofibrate/simvastatin

    Fenofibrate/simvastatin, sold under the brand name Cholib, is a fixed-dose combination medication used to treat abnormal blood lipid levels when used in combination ...

  9. Cardiovascular agents - Wikipedia

    en.wikipedia.org/wiki/Cardiovascular_agents

    Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]