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Gas gangrene (also known as clostridial myonecrosis [1]) is a bacterial infection that produces tissue gas in gangrene. This deadly form of gangrene usually is caused by Clostridium perfringens bacteria. About 1,000 cases of gas gangrene are reported yearly in the United States. [2] Myonecrosis is a condition of necrotic damage, specific to ...
Clostridium perfringens is the most common bacterial agent for gas gangrene. [47] Gas gangrene is induced by α-toxin that embeds itself into the plasma membrane of cells and disrupts normal cellular function by altering membrane structure. [43] Some symptoms include blisters, tachycardia, swelling, and jaundice. [47]
Clostridium perfringens can cause of brain abscesses ... In adults the most common source of ... ulcers, bite wound, [38] anaerobic cellulitis and gas gangrene, ...
There is evidence that adults with seasonal allergies have a unique gut microbiome—which includes the population of bacteria in the digestive system—compared with those who don’t experience ...
The two most prominent infections of GAS are both non-invasive: strep throat (pharyngitis) where it causes 15–30% of the childhood cases and 10% of adult cases, and impetigo. [4] These may be effectively treated with antibiotics. Scarlet fever is also a non-invasive infection caused by GAS, although much less common.
Clostridium perfringens causes a wide range of symptoms, from food poisoning to cellulitis, fasciitis, necrotic enteritis and gas gangrene. [16] [17] Clostridium tetani causes tetanus. Several more pathogenic species, that were previously described in Clostridium, have been found to belong to other genera. [6]
This toxin has been shown to be the key virulence factor in infection with C. perfringens; the bacterium is unable to cause disease without this toxin. [1] Further, vaccination against the alpha toxin toxoid protects mice against C. perfringens gas gangrene. [2]
Although it typically causes mild, cold-like symptoms and most people recover in one to two weeks, it can be a serious infection for infants and older adults, resulting in hospitalization, the CDC ...