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Gas gangrene (also known as clostridial myonecrosis [1]) is a bacterial infection that produces tissue gas in gangrene. This deadly form of gangrene usually is caused by Clostridium perfringens bacteria. About 1,000 cases of gas gangrene are reported yearly in the United States. [2] Myonecrosis is a condition of necrotic damage, specific to ...
Clostridium perfringens is the most common bacterial agent for gas gangrene. [47] Gas gangrene is induced by α-toxin that embeds itself into the plasma membrane of cells and disrupts normal cellular function by altering membrane structure. [43] Some symptoms include blisters, tachycardia, swelling, and jaundice. [47]
This toxin has been shown to be the key virulence factor in infection with C. perfringens; the bacterium is unable to cause disease without this toxin. [1] Further, vaccination against the alpha toxin toxoid protects mice against C. perfringens gas gangrene. [2]
Gas gangrene is a bacterial infection that produces gas within tissues. It can be caused by Clostridium, most commonly alpha toxin-producing C. perfringens, or various nonclostridial species. [9] [19] Infection spreads rapidly as the gases produced by the bacteria expand and infiltrate healthy tissue in the vicinity.
Clostridium perfringens can cause of brain abscesses ... In adults the most common source of ... ulcers, bite wound, [38] anaerobic cellulitis and gas gangrene, ...
Clostridium perfringens causes a wide range of symptoms, from food poisoning to cellulitis, fasciitis, necrotic enteritis and gas gangrene. [16] [17] Clostridium tetani causes tetanus. Several more pathogenic species, that were previously described in Clostridium, have been found to belong to other genera. [6]
Clostridia account for 10% of overall type I infections and typically cause a specific kind of necrotizing fasciitis known as gas gangrene or myonecrosis. Type II infection: This infection accounts for 20 to 30% of cases, mainly involving the extremities.
Welch's research was principally in bacteriology, and he is the discoverer of the organism that causes gas gangrene. It was named Clostridium welchii in recognition of that fact, but now the organism usually is designated as Clostridium perfringens.