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The general mechanism of action for topical antifungal drugs is the disruption of the cell membrane. The unique components found in fungal cell membranes are usually the drug targets of antifungal drugs, in particular ergosterol. It is a sterol, which is important in maintaining proper membrane fluidity and normal functions of the cell membrane.
Antifungal resistance is a subset of antimicrobial resistance, that specifically applies to fungi that have become resistant to antifungals. Resistance to antifungals can arise naturally, for example by genetic mutation or through aneuploidy. Extended use of antifungals leads to the development of antifungal resistance through various ...
As an antifungal, ketoconazole is structurally similar to imidazole, and interferes with the fungal synthesis of ergosterol, a constituent of fungal cell membranes, as well as certain enzymes. As with all azole antifungal agents, ketoconazole works principally by inhibiting the enzyme cytochrome P450 14α-demethylase (CYP51A1). [ 32 ]
Pages in category "Antifungals" The following 99 pages are in this category, out of 99 total. ... Topical antifungal; Trichostatin A; Triclosan; Trimetrexate; U.
Adigun stresses that even prescription-strength topical medications aren't always effective for treating more serious fungal toenail infections. Duration of use. Toenail fungus does not succumb ...
Previously, polyenes were thought to bind to ergosterol in the fungal cell membrane, weakening it and causing leakage of K + and Na + ions, which could contribute to fungal cell death. However, more detailed studies of polyene molecular properties have challenged this model suggesting that polyenes instead bind and extract ergosterol directly ...
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