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Aromatase is localized in the endoplasmic reticulum where it is regulated by tissue-specific promoters that are in turn controlled by hormones, cytokines, and other factors. It catalyzes the last steps of estrogen biosynthesis from androgens (specifically, it transforms androstenedione to estrone and testosterone to estradiol).
“Testosterone doesn’t drop off like estrogen does—it goes down a linear decline,” says Casperson. “Women in their mid-40s and 50s have half the testosterone that we had in our 20s.”
Fat cells have a high amount of aromatase, an enzyme that converts testosterone into estrogen (while estrogen is the primary female sex hormone, men need it too, in small amounts).
Aromatase excess syndrome (AES or AEXS) is a rarely diagnosed genetic and endocrine syndrome which is characterized by an overexpression of aromatase, the enzyme responsible for the biosynthesis of the estrogen sex hormones from the androgens, in turn resulting in excessive levels of circulating estrogens and, accordingly, symptoms of hyperestrogenism.
Although all preparations of a given type of estrogen may be molecularly identical before their introduction into the human body, estrogens administered orally are modified by the liver before entering the bloodstream and most of it is converted to estrone; estrogen bypassing the digestive tract and liver via the skin is not converted to a new ...
Declining testosterone levels and an increase in the level of subcutaneous fatty tissue seen as part of the normal aging process can lead to gynecomastia in older males. Increased fatty tissue, a major site of aromatase activity, leads to increased conversion of androgenic hormones such as testosterone to estrogens. [26]
Hormones naturally work at very low concentrations in the body. This means that even low concentrations of xenohormones in the body can act as an excess and have a profound effect on the body's endocrine system. The levels of hormones present in the body at any given time are tightly controlled through feedback mechanisms.
Testosterone is an essential hormone for both men and women, playing an important role in muscle growth and cognitive function. Low levels of the hormone can lead to changes in mood, cognition and ...
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