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Fatigue is a state of tiredness (which is not sleepiness), exhaustion [1] or loss of energy. [2] [3]Fatigue (in the medical sense) is sometimes associated with medical conditions including autoimmune disease, organ failure, chronic pain conditions, mood disorders, heart disease, infectious diseases, and post-infectious-disease states. [4]
According to a 2000 study, sleep deprivation can have some of the same hazardous effects as being drunk. [46] People who drove after being awake for 17–19 hours performed worse than those with a blood alcohol level of 0.05 percent, which is the legal limit for drunk driving in most western European countries and Australia.
Chronic fatigue with a known cause is twice as common as idiopathic chronic fatigue. [6] Idiopathic chronic fatigue affects between 2.4% and 6.42% of patients, [26] with females more likely to be affected than men. [1] Age at onset is typically over 50 years of age. [13]
In fact, recent research estimates 40% of girls and young women aged 12 to 21 in the US are affected by iron deficiency, with menstruation listed as the primary risk factor. Pregnancy and ...
After fatigue and sleep problems, shortness of breath is the most common heart attack warning sign in women. In one study on 515 women ages 29 to 97 who had heart attacks, shortness of breath ...
[33]: 50 Unrefreshing sleep is a further core symptom. People wake up exhausted and stiff rather than restored after a night's sleep. This can be caused by a pattern of sleeping during the day and being awake at night, shallow sleep, or broken sleep. However, even a full night's sleep is typically non-restorative.
Chronic sleep deprivation also raises the brain's amyloid-beta aggregation, which is linked to neurodegenerative diseases like Alzheimer's. Impaired clearance mechanisms during reduced sleep worsen this neurotoxic environment.Neuroimaging studies also show a shift of cognitive resources, which decreases activation in the prefrontal cortex and ...
Antihistamine effectiveness for sleep may decrease over time, and anticholinergic side-effects (such as dry mouth) may also be a drawback with these particular drugs. While addiction does not seem to be an issue with this class of drugs, they can induce dependence and rebound effects upon abrupt cessation of use. [ 151 ]
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