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Pituitary pars intermedia dysfunction (PPID), or equine Cushing's disease, is an endocrine disease affecting the pituitary gland of horses. It is most commonly seen in older animals, [ 1 ] and is classically associated with the formation of a long, wavy coat ( hirsutism ) and chronic laminitis .
Cushing's is an umbrella term for conditions caused by elevated cortisol and adrenocorticotropic hormone levels. Cushing's disease most commonly refers to pituitary-dependent hyperadrenocorticism, the most common condition of Cushing's syndrome, but 'Cushing's' is used to refer to all hyperadrenocorticism conditions. [2]
Equine metabolic syndrome (EMS) is an endocrinopathy affecting horses and ponies. It is of primary concern due to its link to obesity, insulin dysregulation , and subsequent laminitis .
Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, [3] when excluding Cushing's syndrome from exogenously administered corticosteroids. The equine version of this disease is Pituitary pars intermedia dysfunction. This should not be confused with ectopic Cushing syndrome or exogenous steroid use. [4]
Vitex agnus-castus (also called vitex, chaste tree / chastetree, chasteberry, Abraham's balm, [1] lilac chastetree, [2] or monk's pepper) is a plant native of the Mediterranean region. It is one of the few temperate-zone species of Vitex , which is on the whole a genus of tropical and subtropical flowering plants . [ 3 ]
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