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Domoic acid (DA) is a kainic acid-type neurotoxin that causes amnesic shellfish poisoning (ASP). [1] It is produced by algae and accumulates in shellfish , sardines , and anchovies . When sea lions, otters, cetaceans, humans, and other predators eat contaminated animals, poisoning may result.
Amnesic shellfish poisoning (ASP) is an illness caused by consumption of shellfish that contain the marine biotoxin called domoic acid. [1] In mammals , including humans, domoic acid acts as a neurotoxin , causing permanent short-term memory loss , brain damage , and death in severe cases.
The diatom lineage may go back 180 to 250 million years ago (Mya). About 65 Mya, diatoms survived a mass extinction in which roughly 85% of all species perished. [6] Until 1994, the genus was known as Nitzschia, but was changed to Pseudo-nitzschia because of the ability to form chains of overlapping cells, as well as other minor morphological differences. [8]
Pseudo-nitzschia australis is a pennate diatom found in temperate and sub-tropic marine waters, such as off the coast of California and Argentina. This diatom is a Harmful Micro Algae [1] that produces toxic effects on a variety of organisms through its production of domoic acid, a neurotoxin.
Nitzschia is found mostly in colder waters, and is associated with both Arctic and Antarctic polar sea ice, where it is often found to be the dominant diatom. Nitzschia includes several species of diatoms known to produce the neurotoxin known as domoic acid, a toxin responsible for the human illness called amnesic shellfish poisoning.
Poisoning is the harmful effect which occurs when toxic substances are introduced into the body. [1] The term "poisoning" is a derivative of poison, a term describing any chemical substance that may harm or kill a living organism upon ingestion. [2] Poisoning can be brought on by swallowing, inhaling, injecting or absorbing toxins through the skin.
Saxitoxin is a neurotoxin naturally produced by certain species of marine dinoflagellates (Alexandrium sp., Gymnodinium sp., Pyrodinium sp.) and freshwater cyanobacteria (Dolichospermum cicinale sp., some Aphanizomenon spp., Cylindrospermopsis sp., Lyngbya sp., Planktothrix sp.) [1] [2] Saxitoxin accumulates in "planktivorous invertebrates, including mollusks (bivalves and gastropods ...
Brevetoxin (PbTx), or brevetoxins, are a suite of cyclic polyether compounds produced naturally by a species of dinoflagellate known as Karenia brevis.Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes and causing the illness clinically described as neurotoxic shellfish poisoning (NSP). [1]