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Mast cells are a part of your immune system. They’re made in your bone marrow, then move through your bloodstream into your tissues. The mature mast cells live in tissues throughout your body to help protect you from hazards around you. They can help fight infections and regulate your organs.
A mast cell (also known as a mastocyte or a labrocyte[1]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.
Mast cells are long-lived tissue-resident cells with an important role in many inflammatory settings including host defence to parasitic infection and in allergic reactions.
Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings.
Mast cells reside within the connective tissue of a variety of tissues and all vascularized organs. Their numbers and densities are highest at interfaces between the internal and external environments where they can respond to foreign organisms and antigens, providing a sentinel function [6].
Mast cells (MCs) play important roles in normal immune responses and pathological states. The location of MCs on the boundaries between tissues and the external environment, including gut mucosal surfaces, lungs, skin, and around blood vessels, suggests a multitude of immunological functions.
Mast-cell mediators affect the mucosa, the blood vessels and sensory nerves at sites of allergy; mast-cell proteases and cytokines contribute to the initiation of a facultative late-phase...
Mast cells often represent one of the first cells of the immune system to interact with environmental antigens, invading pathogens or environmentally-derived toxins. Mast cells also can undergo alterations in phenotype, anatomic distribution and numbers during innate or adaptive immune responses.
This review summarizes our knowledge of mast cells in innate and acquired immunity, allergic inflammation and tissue homeostasis, as well as some of the regulatory mechanisms that...
mast cell, tissue cell of the immune system of vertebrate animals. Mast cells mediate inflammatory responses such as hypersensitivity and allergic reactions.