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2'-O-methylation (2'-O-Me) is a common nucleotide epitranscriptomics modification of ribosomal RNA (rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. [ 1 ] The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the ...
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U25 is found in gene clusters in plants [2] and within the U22 snoRNA host gene (UHG) in mammals. [3] U25 is thought to as a 2'-O-ribose methylation guide for ribosomal RNA. This RNA has also been named snoRNA R73 in some plants.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] This snoRNA was originally cloned from HeLa cells and expression verified by northern blotting. [2] It is predicted to guide 2'O-ribose methylation of ribosomal RNA (rRNA) 28S at residue C3866.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U20 is encoded in intron 11 of the nucleolin gene in human, mouse and rat. [2] It is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue U1804. [3] [4]
This snoRNA was originally cloned from HeLa cells and experimentally verified by northern blotting. [2] SNORD48 is predicted to guide the 2'O-ribose methylation of 28S rRNA C2279. [ 3 ] In the human genome this snoRNA is located in the introns of the same host gene (C6orf48) as another C/D box snoRNA U52 (also known as SNORD52).
This family functions to direct site-specific 2'-O-methylation of substrate RNAs. [1] This snoRNA was originally cloned from human HeLa cells during a screen for intron encoded snoRNAs. [2] It is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue A99 3
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U52 was originally cloned from HeLa cells and is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) residue U3904. [2] [3] U52 and the C/D box snoRNA U48 are encoded in the introns of the same host gene ...
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [ 1 ] snoRNA HBII-166 is the human orthologue of the mouse MBII-166 [ 2 ] and is predicted to guide 2'O-ribose methylation of spliceosomal RNA U6 at residue C60.