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In pharmacology, the fibrates are a class of amphipathic carboxylic acids and esters. They are derivatives of fibric acid (phenoxyisobutyric acid). They are used for a range of metabolic disorders, mainly hypercholesterolemia (high cholesterol ), and are therefore hypolipidemic agents .
FibroTest, known as FibroSure in the US, is a biomarker test that uses the results of six blood serum tests to generate a score that is correlated with the degree of liver damage in people with a variety of liver diseases. FibroTest has the same prognostic value as a liver biopsy.
Fibrates are hypolipidemic agents primarily used for decreasing serum triglycerides, while increasing High density lipoprotein (HDL). Subcategories. This category has ...
Simfibrate (JAN/INN; trade name Cholesolvin) is a fibrate that has been used for the treatment of hyperlipidemia. [1] [2] The substance is a double ester of clofibric acid with 1,3-propanediol which is cleaved in the body to one molecule of 1,3-propanediol and two molecules of clofibric acid which is the true lipid-lowering agent.
Clinofibrate (trade name Lipoclin) is a fibrate and a derivative of Bisphenol Z. [1] Synthesis. The reaction between cyclohexanone and phenol gives Bisphenol Z (3). [2]
An example of a positive Seliwanoff’s test. Seliwanoff’s test is a chemical test which distinguishes between aldose and ketose sugars.If the sugar contains a ketone group, it is a ketose.
Ronifibrate is a fibrate, a hypolipidemic agent. It is a combined ester of clofibric acid and niacin (nicotinic acid) with 1,3-propanediol . In the body, the ester is split to 1,3-propanediol and both acids which work in the same way, lowering lipids in blood.
Ciprofibrate is a fibrate that was developed as a lipid-lowering agent. It was patented in 1972 and approved for medical use in 1985. [1] References
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