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Cite this page; Get shortened URL; Download QR code ... ionic selectivity for potassium channels was that ... move through the free solution. In many ion channels ...
Bertil Hille pioneered the concept of ion channels as membrane proteins forming gated aqueous pores (with Clay Armstrong). [6] [7] He showed that Na+ and K+ channels of axons could be distinguished by drugs such as tetrodotoxin and tetraethylammonium ion, and that their ionic selectivity can be understood by limiting pore size, the selectivity filter, and by movements of ions through a series ...
These ion channels, once activated, allow for the flow of potassium ions (K +) from the extracellular space surrounding the cell across the plasma membrane and into the cytoplasm. Each channel consists of domains which span the plasma membrane, forming the K +-selective pore region through which the K + ions will flow.
Voltage-gated ion-channels are usually ion-specific, and channels specific to sodium (Na +), potassium (K +), calcium (Ca 2+), and chloride (Cl −) ions have been identified. [1] The opening and closing of the channels are triggered by changing ion concentration, and hence charge gradient, between the sides of the cell membrane.
Voltage-gated proton channels are ion channels that have the unique property of opening with depolarization, but in a strongly pH-sensitive manner. [1] The result is that these channels open only when the electrochemical gradient is outward, such that their opening will only allow protons to leave cells .
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For example, the addition of a light-gated component allows for the introduction of many highly similar ligands to be introduced to the binding site of a ligand-gated ion channel to assist in the determination of the mechanism. Such ion channels have been modified by binding a photoswitch to confer photosensitivity on the ion channel.
Download as PDF; Printable version; In other projects Wikidata item; ... A channel modulator, or ion channel modulator, is a type of drug which modulates ion channels.