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BCEM, also referred to as conjunctival hypermelanosis, complexion-associated melanosis, or racial melanosis, is a non-cancerous lesion of the conjunctiva that is more commonly found in dark-skinned individuals (over 90% of lesions are found in black persons and around 5% in white persons). [1]
Other anomalies may be present concurrently, including cleft palate, cleft lip, or mandibular hypoplasia. There is a known association with Goldenhar syndrome (oculo-auriculo-vertebral syndrome) [8] and with Wildervanck syndrome. [9] [10] [11] There may also be an association with congenital cartilaginous rest of the neck.
The conjunctiva is a tissue that lines the inside of the eyelids and covers the sclera. It is composed of unkeratinized, stratified squamous epithelium with goblet cells, and stratified columnar epithelium. The conjunctiva is basically transparent, and the white colour we see is actually sclera.
Scleral translucency following recurrent scleritis. Symptoms of scleritis include: [3] Redness of the sclera and conjunctiva, sometimes changing to a purple hue; Severe ocular pain, which may radiate to the temple or jaw. The pain is often described as deep or boring. Photophobia and tearing; Decrease in visual acuity, possibly leading to blindness
It is seen as a yellow-white deposit on the conjunctiva adjacent to the limbus (the junction between the cornea and sclera). [3] (It is to be distinguished clinically from a pterygium, which is a wedge shaped area of fibrosis that may grow onto the cornea.) A pinguecula usually does not cause any symptoms.
Conjunctival squamous cell carcinoma (conjunctival SCC) and corneal intraepithelial neoplasia comprise ocular surface squamous neoplasia (OSSN). SCC is the most common malignancy of the conjunctiva in the US, with a yearly incidence of 1–2.8 per 100,000.
(H10.0) Conjunctivitis – inflammation of the conjunctiva commonly due to an infection or an allergic reaction (H11.129) Conjunctival concretion - development of hard deposits under the eyelid H15-H22 Disorders of sclera, cornea, iris and ciliary body
CHIME syndrome, also known as Zunich–Kaye syndrome or Zunich neuroectodermal syndrome, is a rare congenital ichthyosis first described in 1983. [1] The acronym CHIME is based on its main symptoms: colobomas, heart defects, ichthyosiform dermatosis, intellectual disability, and either ear defects or epilepsy. [2]