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The first reported case of reinfection was a 33-year-old man from Hong Kong who first tested positive on 26 March 2020, was discharged on 15 April 2020 after two negative tests, and tested positive again on 15 August 2020 (142 days later), which was confirmed by whole-genome sequencing showing that the viral genomes between the episodes belong ...
Accuracy is measured in terms of specificity and selectivity. Test errors can be false positives (the test is positive, but the virus is not present) or false negatives, (the test is negative, but the virus is present). [179] In a study of over 900,000 rapid antigen tests, false positives were found to occur at a rate of 0.05% or 1 in 2000. [180]
The Proximal Origin is a reference to a scientific correspondence titled "The proximal origin of SARS-CoV-2" and the events of scientific and political controversies arising from it. [ 1 ] [ 2 ] The letter, published in the journal Nature Medicine on 17 March 2020, was written by a group of virologists including Kristian G. Andersen , Andrew ...
Since the first cases of a mysterious new respiratory illness were recorded in China in late 2019, scientists have come to know the pathogen named SARS-CoV-2 (along with its Greek-letter variants ...
After cross-species transmission of a virus, rapid evolution and positive selection are expected. [47] Several studies found only weak signs of adaptive evolution early in the COVID-19 pandemic. [ c ] Kang et al. wrote that SARS-CoV-2 had exhibited relatively little genetic variation by 2021. [ 47 ]
The frameshift occurs at a slippery sequence which is followed by a pseudoknot RNA secondary structure. [1] This has been measured at between 20-50% efficiency for murine coronavirus, [6] or 45-70% in SARS-CoV-2 [7] yielding a stoichiometry of roughly 1.5 to 2 times as much pp1a as pp1ab protein expressed. [2]
In May 2020, a rapid antigen test from Quidel Corporation received EUA for detecting SARS-CoV-2. [8] Test results were said to be available at point of care within 15 minutes. [9] Sensitivity is 85%. [1] Also in May 2020, a CRISPR genetic test was approved for emergency use that claimed 100% selectivity and 97.5% sensitivity. [10] That month ...
The first scientist to publish a sequence of the COVID-19 virus in China staged a sit-in protest outside his lab after authorities locked him out of the facility — a sign of the Beijing's ...