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A 2018 pooled analysis from three phase III, randomized, double-blind, placebo-controlled studies on usage for Opioid-Induced Constipation, found that the numbers of patients reporting adverse effects were similar in both the lubiprostone and placebo treatment groups for all opioid classes (P ≥ 0.125); however, gastrointestinal adverse ...
Syrup of Figs Commercial Preparation. Syrup of figs is a formerly proprietary preparation for use as a laxative, now widely available commercially and also easy to make at home. Its ingredients include figs and dried senna pods, both known for their laxative properties, as well as water, sugar and lemon. [1]
Naldemedine, sold under the brand name Symproic in the US and Rizmoic in the European Union, is a medication that is used for the treatment of opioid-induced constipation in adults who have previously been treated with a laxative in the European Union, or to treat opioid induced constipation in adults with chronic non-cancer pain in the US.
Some of the less significant adverse effects of laxative abuse include dehydration (which causes tremors, weakness, fainting, blurred vision, kidney damage), low blood pressure, fast heart rate, postural dizziness and fainting; [26] however, laxative abuse can lead to potentially fatal acid-base, and electrolyte imbalances. [26]
Sodium picosulfate is a prodrug. [5] It has no significant direct physiological effect on the intestine; however, it is metabolised by gut bacteria into the active compound 4,4'-dihydroxydiphenyl-(2-pyridyl)methane (DPM, BHPM).
Bisacodyl is an organic compound that is used as a stimulant laxative drug. It works directly on the colon to produce a bowel movement. It is typically prescribed for relief of episodic and chronic constipation and for the management of neurogenic bowel dysfunction, as well as part of bowel preparation before medical examinations, such as for a colonoscopy.
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Oxyphenisatine (or oxyphenisatin) is a laxative. [3] It is closely related to bisacodyl, sodium picosulfate, and phenolphthalein.Long-term use is associated with liver damage, [4] and as a result, it was withdrawn in most countries in the early 1970s.