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Marbofloxacin can be used both orally and topically. It is particularly used for infections of the skin, respiratory system and mammary glands in dogs and cats, as well as with urinary tract infections. For dogs, a dose ranges from 2.75 - 5.5 mg/kg once a day.
Dogs receiving 10 times the labeled dosage rate of enrofloxacin for at least 14 days developed only vomiting and anorexia. Death did occur in some dogs when fed 25 times the labeled rate for 11 days, however. Oral LD 50: greater than 5000 mg/kg; Dermal LD 50: greater than 2000 mg/kg; Inhalation LD 50: greater than 3547 mg/m3 (4-hour exposure)
Bioavailability is 91% at the standard subcutaneous dose but 24% at the standard oral dose; the standard oral dose is higher to partially compensate for incomplete bioavailability. [ 5 ] [ 18 ] It binds to plasma proteins at a rate of 99.5%; it has a low volume of distribution (9 L/kg) and is thus not extensively absorbed.
The vomer (/ ˈ v oʊ m ər /; [1] [2] Latin: vomer, lit. 'ploughshare') is one of the unpaired facial bones of the skull . It is located in the midsagittal line, and articulates with the sphenoid , the ethmoid , the left and right palatine bones, and the left and right maxillary bones.
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Vomer bone The lowest part of the septum is a narrow strip of bone that projects from the maxilla and the palatine bones , and is the length of the septum. This strip of bone is called the maxillary crest; it articulates in front with the septal nasal cartilage, and at the back with the vomer. [ 5 ]
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