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Donepezil, sold under the brand name Aricept among others, is a medication used to treat dementia of the Alzheimer's type. [3] [4] [8] It appears to result in a small benefit in mental function and ability to function. [9]
Memantine/donepezil, sold under the brand name Namzaric among others, is a fixed dose combination medication used for the treatment of dementia of the Alzheimer's type. [1] It contains memantine, as the hydrochloride, a NMDA receptor antagonist; and donepezil as the hydrochloride, an acetylcholinesterase inhibitor. [1] It is taken by mouth. [1]
Cholinesterase inhibitors (Aricept, Razadyne, Exelon): One major cause of Alzheimer's symptoms is decreased production of acetylcholine in the brain, a chemical messenger key to judgment, thought ...
Aricept – used to slow the progression of Alzheimer's disease Ativan ( lorazepam ) – a benzodiazepine , used to treat anxiety Asendin ( amoxapine ) – an dibenzoxazepine antidepressant
In a large clinical trial of the rivastigmine patch in 1,195 patients with Alzheimer's disease, the target dose of 9.5 mg/24-hour patch provided similar clinical effects (e.g. memory and thinking, activities of daily living, concentration) as the highest doses of rivastigmine capsules, but with one-third fewer reports of nausea and vomiting. [8]
Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. [14] [11] [7]In 2015, the United States Food and Drug Administration's Adverse Event Reporting System database compared rivastigmine to the other ChEI drugs donepezil and galantamine found that rivastigmine was associated with a higher frequency of reports of death as an adverse event.
Each month, doses of 0.1 mg/kg to 10 mg/kg were injected into males and non-fertile females at an average age of 74. [11] Lilly revealed that there were adverse effects for the 37 people who received the treatment and 12 volunteers who received the placebo. The highest dose of donanemab reduced the effect of the plaque burden in the brain. [10]
Cues can be used to help with memory retrieval. [39] For autonomic dysfunction, several non-medication strategies may be helpful. Dietary changes include avoiding meals high in fat [77] and sugary foods, eating smaller and more frequent meals, [182] after-meal walks, and increasing fluids or dietary fiber to treat constipation. [77]
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