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Paul Edward Stamets (born July 17, 1955) [3] is an American mycologist and entrepreneur who sells various mushroom products through his company. He is an author and advocate of medicinal fungi and mycoremediation .
Some chemical defenses once thought to be produced by the plant have since been shown to be synthesized by endophytic fungi. The chemical basis of insect resistance in endophyte-plant defense mutualisms has been most extensively studied in the perennial ryegrass and three major classes of secondary metabolites are found: indole diterpenes, ergot alkaloids and peramine.
Defensins are small cysteine-rich cationic proteins across cellular life, including vertebrate [1] and invertebrate [2] animals, plants, [3] [4] and fungi. [5] They are host defense peptides, with members displaying either direct antimicrobial activity, immune signaling activities, or both.
[11] [12] [13] Hyphae are too large for cell-mediated internalization, and thus neutrophil-mediated NADPH-oxidase induced damage represents the dominant host defense against hyphae. [ 11 ] [ 13 ] In addition to these cell-mediated mechanisms of elimination, antimicrobial peptides secreted by the airway epithelium contribute to host defense. [ 11 ]
Animal models indicate that host defense peptides are crucial for both prevention and clearance of infection. It appears as though many peptides initially isolated as and termed "antimicrobial peptides" have been shown to have more significant alternative functions in vivo (e.g. hepcidin [18]). Dusquetide for example is an immunomodulator that ...
The former Cardinals and Broncos QB believes mushrooms are a better treatment choice than traditional medicine. ... Plummer is a co-founder of Mycolove Farm, which has been selling locally grown ...
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