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Clofazimine also showed a dosage-dependent inhibition of neutrophil motility, lymphocyte transformation, [19] mitogen-induced PBMC proliferation [20] and complement-mediated solubilization of pre-formed immune complexes in vitro. [21] A mechanistic studying of clofazimine in human T cells revealed that this drug is a Kv1.3 channel blocker. [22]
Pages in category "4-Chlorophenyl compounds" The following 200 pages are in this category, out of approximately 257 total. This list may not reflect recent changes .
Carbinoxamine is an antihistamine and anticholinergic agent.It is used for hay fever, vasomotor rhinitis, mild urticaria, angioedema, dermatographism and allergic conjunctivitis.
Maleimide-mediated methodologies are among the most used in bioconjugation. [5] [6] Due to fast reactions and high selectivity towards cysteine residues in proteins, a large variety of maleimide heterobifunctional reagents are used for the preparation of targeted therapeutics, assemblies for studying proteins in their biological context, protein-based microarrays, or proteins immobilisation. [7]
Rilmazafone [1] (リスミー, Rhythmy, previously known as 450191-S) is a water-soluble prodrug developed in Japan. [2] Inside the human body, rilmazafone is converted into several benzodiazepine metabolites that have sedative and hypnotic effects.
Relative to PCA, 4-CAB is also substantially less effective as a serotonergic neurotoxin. [1] A single 10 mg/kg administration of PCA to rats produces an approximate 80% decrease in serotonin markers as observed 1 week later. [1] In contrast, 11 mg/kg and 22 mg/kg doses of 4-CAB result in only 20% and 50% decreases, respectively. [1]
Benzotript (INN Tooltip International Nonproprietary Name), also known as N-(p-chlorobenzoyl)-L-tryptophan, is a muscle relaxant that inhibits gastric secretion and was never marketed. [ 1 ] [ 2 ] It is a tryptamine derivative and the N -(4-chlorobenzoyl) analogue of the amino acid tryptophan . [ 1 ]
key:paebejvpsadomc-hszrjfapsa-n PF-04745637 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, with an IC 50 of 17nM, vs ~3μM at the related TRPV1 and TRPM channels.