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The active ingredients are imidacloprid, permethrin, and pyriproxyfen. This product is toxic to cats, [ 2 ] and it is not recommended to use it on dogs which share an environment with cats. [ 1 ] The product is applied onto the skin; administration of the product into the mouth can cause adverse effects.
Permethrin is a medication and an insecticide. [6] [7] As a medication, it is used to treat scabies and lice. [8]It is applied to the skin as a cream or lotion. [6] As an insecticide, it can be sprayed onto outer clothing or mosquito nets to kill the insects that touch them.
Medical cases have emerged showing fatalities from the use of pyrethrin, prompting many organic farmers to cease use. One fatal case of an 11-year-old girl with a known asthmatic condition and who used shampoo containing only a small amount (0.2% pyrethrin) to wash her dog was documented. [28]
Cypermethrin is very toxic to cats which cannot tolerate the therapeutic doses for dogs. [6] This is associated with UGT1A6 deficiency in cats, the enzyme responsible for metabolizing cypermethrin. As a consequence, cypermethrin remains much longer in the cat's organs than in dogs or other mammals and can be fatal in large doses.
Phenothrin, also called sumithrin and d-phenothrin, [2] is a synthetic pyrethroid that kills adult fleas and ticks.It has also been used to kill head lice in humans. d-Phenothrin is used as a component of aerosol insecticides for domestic use.
Imiprothrin is a synthetic pyrethroid insecticide.It is an ingredient in some commercial and consumer insecticide products for indoor use. It has low acute toxicity to humans through the inhalation and dermal routes, but to insects it acts as a neurotoxin causing paralysis.
Cyhalothrin (ISO common name [3]) is an organic compound that, in specific isomeric forms, is used as a pesticide. [4] It is a pyrethroid, a class of synthetic insecticides that mimic the structure and properties of the naturally occurring insecticide pyrethrin which is present in the flowers of Chrysanthemum cinerariifolium.
Allethrin I (R = −CH 3) Allethrin II (R = −COOCH 3). The allethrins are a group of related synthetic compounds used in insecticides.They are classified as pyrethroids, i.e. synthetic versions of pyrethrin, a chemical with insecticidal properties found naturally in Chrysanthemum flowers.
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