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2 - Developing follicle 3 - Mature follicle 4 - Ovulation 5 - Corpus luteum 6 - Deterioration of corpus luteum. In biology, folliculogenesis is the maturation of the ovarian follicle, a densely packed shell of somatic cells that contains an immature oocyte.
Mural granulosa cells (MGC) line the follicular wall and surround the fluid-filled antrum. The oocyte secretes factors that determine the functional differences between CCs and MGCs. CCs primarily support growth and development of the oocyte whereas MGCs primarily serve an endocrine function and support the growth of the follicle.
The larger ovarian follicles consist of an external fibrovascular coat, connected with the surrounding stroma of the ovary by a network of blood vessels, and an internal coat, which consists of several layers of nucleated cells, called the membrana granulosa. It contains numerous granulosa cells.
An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries. It secretes hormones that influence stages of the menstrual cycle . In humans, women have approximately 200,000 to 300,000 follicles at the time of puberty , [ 1 ] [ 2 ] each with the potential to release an egg cell (ovum) at ovulation for fertilization ...
The anterior pituitary complex and hypophyseal portal system, where FSH and LH are released. Theca cells are responsible for synthesizing androgens, providing signal transduction between granulosa cells and oocytes during development by the establishment of a vascular system, providing nutrients, and providing structure and support to the follicle as it matures.
Oocyte abnormalities can be caused by a variety of genetic factors affecting different stages in meiosis. [1] Moreover, ageing is associated with oocyte abnormalities since higher maternal age is associated with oocytes with a reduced gene expression of spindle assembly checkpoints which are important in maintaining stability in the genome.
These cells are derived from the mesoderm during embryonic development and are closely related to the mesothelium of the peritoneum.The germinal epithelium gives the ovary a dull gray color as compared with the shining smoothness of the peritoneum; and the transition between the mesothelium of the peritoneum and the cuboidal cells which cover the ovary is usually marked by a line around the ...
Stromal cells associated with maturing follicles may acquire endocrine function and secrete estrogens. The entire ovarian stroma is highly vascular. [1] On the surface of the organ this tissue is much condensed, and forms a layer (tunica albuginea) composed of short connective-tissue fibers, with fusiform cells between them.