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In vitro studies, 25C-NBOMe has been shown to exhibit cytotoxicity on neuronal cell lines SH-SY5Y, PC12, and SN471, and the compound was more potent than methamphetamine at reducing the visibility of the respective cells; the neurotoxicity of the compound involves activation of MAPK/ERK cascade and inhibition of Akt/PKB signaling pathway.
In vitro studies, 25C-NBOMe has been shown to exhibit cytotoxicity on neuronal cell lines SH-SY5Y, PC12, and SN471, and the compound was more potent than methamphetamine at reducing the visibility of the respective cells; the neurotoxicity of the compound involves activation of MAPK/ERK cascade and inhibition of Akt/PKB signaling pathway.
In vitro studies, 25C-NBOMe has been shown to exhibit cytotoxicity on neuronal cell lines SH-SY5Y, PC12, and SN471, and the compound was more potent than methamphetamine at reducing the visibility of the respective cells; the neurotoxicity of the compound involves activation of MAPK/ERK cascade and inhibition of Akt/PKB signaling pathway.
25N-NBOMe (2C-N-NBOMe, NBOMe-2C-N) is a derivative of the hallucinogen 2C-N. The pharmacological properties of 25N-NBOMe have not been described in the scientific literature, but it is believed to act in a similar manner to related compounds such as 25I-NBOMe and 25C-NBOMe , which are potent agonists at the 5HT 2A receptor .
25CN-NBOH is notable as one of the most selective agonists of the serotonin 5-HT 2A receptor yet discovered, with an affinity (pK i) of 8.88 at the human serotonin 5-HT 2A receptor, 100-fold selectivity for the serotonin 5-HT 2A receptor over the serotonin 5-HT 2C receptor, and 46-fold selectivity for the serotonin 5-HT 2A receptor over the serotonin 5-HT 2B receptor.
A woman who underwent a trial immunotherapy as a child for neuroblastoma — an aggressive nerve tissue tumor that occurs often in children under 5 — has since been in remission for 18 years ...
25TFM-NBOMe (also known as NBOMe-2C-TFM, 2C-TFM-NBOMe, and Cimbi-138) is a derivative of the phenethylamine hallucinogen 2C-TFM, discovered in 2004 by Ralf Heim at the Free University of Berlin. [1]
Image credits: Michael Buckner / Getty #3 Scott Disick. Boxes of Mounjaro, which is known for its weight loss effects, were found stacked in Scott Disick’s fridge on a past episode of The ...