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Topical cream formulation is an emulsion semisolid dosage form that is used for skin external application. Most of the topical cream formulations contain more than 20 per cent of water and volatiles and/or less than 50 per cent of hydrocarbons , waxes , or polyethylene glycols as the vehicle for external skin application. [ 1 ]
Acetophenone is formed as a byproduct of the cumene process, the industrial route for the synthesis of phenol and acetone.In the Hock rearrangement of isopropylbenzene hydroperoxide, migration of a methyl group rather than the phenyl group gives acetophenone and methanol as a result of an alternate rearrangement of the intermediate:
British researchers found evidence that using the cream to moisturize areas affected by eczema may actually aggravate the condition. [2] They suggested this was due to skin-thinning effects of a detergent sodium lauryl sulfate. The National Eczema Society recommends alternatives such as white soft paraffin wax or other types of emollient ...
Topical drug delivery (TDD) is a route of drug administration that allows the topical formulation to be delivered across the skin upon application, hence producing a localized effect to treat skin disorders like eczema. [1] [2] The formulation of topical drugs can be classified into corticosteroids, antibiotics, antiseptics, and anti-fungal.
Products of decomposition of cumene hydroperoxide are methylstyrene, acetophenone, and 2-phenylpropan-2-ol. [3] It is produced by treatment of cumene with oxygen, an autoxidation. At temperatures >100 °C, oxygen is passed through liquid cumene: [4] C 6 H 5 CH(CH 3) 2 + O 2 → C 6 H 5 C(CH 3) 2 OOH. Dicumyl peroxide is a side product.
Benzene was also detected in Proactiv, PanOxyl, Walgreens' acne soap bar and Walmart's Equate Beauty acne cream among others, according to Valisure. Cancer-causing chemical found in Clinique ...
[3] [1] [6] [10] Gel characteristics include stability, thermodynamic activity, and occlusive properties. [3] [1] [10] Following penetration through the skin barrier, the drug may permeate through deeper skin tissues and reach the blood capillaries in the dermis. [6] [9] It may then proceed to enter the systemic circulation for systemic effect ...
Ointments are more occlusive than aqueous creams, which are more occlusive than lotion. [5] Water loss through the skin is normally about 4–8 g/(m 2 ⋅h). A layer of petrolatum applied to normal skin can reduce that loss by 50–75% for several hours. [4] Oils naturally produced by the human body moisturize through this same mechanism. [2]
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