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Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. [3] By intravenous injection it is used for treatment of colorectal cancer , oesophageal cancer , stomach cancer , pancreatic cancer , breast cancer , and cervical cancer . [ 3 ]
Pain in the vein during the infusion of oxaliplatin or folinic acid – This can be managed by decreasing the rate of infusion. Some people develop soreness, redness and peeling on the palms of the hands and soles of the feet (plantar palmar syndrome). This may cause tingling, numbness, pain and dryness.
Weight gain can also be caused by some steroid medications. These side-effects can frequently be reduced or eliminated with antiemetic drugs. Low-certainty evidence also suggests that probiotics may have a preventative and treatment effect of diarrhoea related to chemotherapy alone and with radiotherapy. [ 86 ]
Weight fluctuations of five pounds are more are uncommon among men. Experts explain common sudden weight gain causes, what to do, and when to see a doctor. 12 Common Causes of Sudden Weight Gain
However, many are associated with an infamous side effect: weight gain. Luckily, some antidepressants are less likely to cause weight gain than others. In fact, there are even some antidepressants ...
“Clinicians and patients can use this information, among other factors, to help decide on the right choice for them,” he added. Greatest risk of at least 5% weight gain at six months of use ...
There are currently several fluoropyrimidine-related chemotherapy treatments, such as 5-fluorouracil (5-FU), that are limited by drug chemoresistance. [5] But it has been shown that the conjugation of FdUMP with folic acid (FA) by a phosphodiester bonding shows improved cytotoxicity to both human and 5-FU-resistant colorectal tumor cells .
The "pharmacogenetics" section contains the sentence: "The FDA-approved drug label for fluorouracil states that the drug is contraindicated in patients with known DPD deficiency.[6]" This is not mentioned in the "contraindications" section; should this sentence or similar, or even the section, be added, or moved there (merged or as a subsection ...