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A study found that a single intramuscular injection of 5 mg estradiol valerate resulted in peak circulating levels of 667 pg/mL estradiol and 324 pg/mL estrone within approximately 2 and 3 days, respectively. [10] The duration of estradiol valerate at this dose and in this study was considered to be 7 to 8 days. [10]
Estradiol, mainly as esters including estradiol valerate, estradiol cypionate, and estradiol enanthate, is also the exclusive estrogen used in combined injectable contraceptives. [ 6 ] As of 2021, more than 95% of prescriptions are for combined hormonal birth control forms containing the synthetic estrogen ethinylestradiol (EE). [ 7 ]
5 mg 1x/week Estradiol valerate: 10–40 mg 1x/1–2 weeks Estradiol undecylate: 100 mg 1x/4 weeks Polyestradiol phosphate: Alone: 160–320 mg 1x/4 weeks With oral EE: 40–80 mg 1x/4 weeks Estrone: 2–4 mg 2–3x/week IV injection: Fosfestrol: 300–1200 mg 1–7x/week Estramustine phosphate: 240–450 mg/day Note: Dosages are not ...
Femilar, which is an estradiol-containing birth control pill, contains 1 to 2 mg estradiol valerate and 1 to 2 mg CPA, and has been approved for use in Finland since 1993. [5] CPA alone has been found to suppress ovulation in 3 of 5 women at a dose of 0.5 mg/day and in 5 of 5 women at a dose of 1 mg/day.
Estradiol (E2) is a medication and naturally occurring steroid hormone. [11] [12] [13] It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women.
Estradiol valerate 2.5 to 5 mg + norethisterone enantate 50 to 80 mg in an oil solution [15] [16] Estradiol valerate 10 mg + hydroxyprogesterone caproate 500 mg in an oil solution [15] Estradiol cypionate 2.5 to 10 mg + medroxyprogesterone acetate 12.5 to 50 mg in a microcrystalline aqueous suspension [15] [16]
Estradiol valerate/prasterone enanthate (EV/DHEA-E), sold under the brand name Gynodian Depot among others, is an injectable combination medication of estradiol valerate (EV), an estrogen, and prasterone enanthate (DHEA-E), an androgen, estrogen, and neurosteroid, which is used in menopausal hormone therapy for women.
Estradiol valerate/hydroxyprogesterone caproate (EV/OHPC), sold under the brand names Gravibinon and Injectable No. 1 (or Chinese Injectable No. 1) among others, is a combined estrogen and progestogen medication which is used in the treatment of threatened miscarriage and other indications (e.g., as a means of pseudopregnancy) [1] [2] [3] and as a form of combined injectable birth control to ...