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In partial moles, some villi are vesicular, whereas others appear more normal, and embryonic/fetal development may be seen but the fetus is always malformed and is never viable. Uterus with complete hydatidiform mole. In rare cases, a hydatidiform mole co-exists in the uterus with a normal, viable fetus. These cases are due to twinning. The ...
Invasive hydatidiform mole is a type of neoplasia that grows into the muscular wall of the uterus. It is formed after conception ( fertilization of an egg by a sperm ). It may spread to other parts of the body, such as the vagina , vulva , and lung .
Hydatidiform mole; Here, first a fertilised egg implants into the uterus, but some cells around the fetus (the chorionic villi) do not develop properly. The pregnancy is not viable, and the normal pregnancy process turns into a benign tumour. There are two subtypes of hydatidiform mole: complete hydatidiform mole, and partial hydatidiform mole.
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Epidemiological studies have reported that hydatidiform mole appears to be caused by abnormal gametogenesis and fertilization more frequent at the extremes of reproductive age of younger than 15 and older than 45 years of age and pregnancies at these ages are a risk factor for hydatidiform mole.
Common characteristic manifestations of gestational choriocarcinoma include irregular vaginal bleeding and hydatidiform moles. A hydatidiform mole is a red hemorrhagic mass with various sizes in the uterus. [14] Often, diagnosis is presumptive. It is based on clinical findings and the identification of a malignant trophoblast. One prevalent ...
Theca lutein cysts are also often notably seen in patients with choriocarcinoma or hydatidiform mole. [7] Rarely these type of cysts are present in normal pregnancy. In the event they do occur in otherwise uncomplicated pregnancies they are most likely associated with elevated levels of beta-hCG. [9]
Since gestational choriocarcinoma (which arises from a hydatidiform mole) contains paternal DNA (and thus paternal antigens), it is exquisitely sensitive to chemotherapy. The cure rate, even for metastatic gestational choriocarcinoma, is more than 90% when using chemotherapy for invasive mole and choriocarcinoma. [7]