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Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D3 (abbreviated 25 (OH)D3), [1] is a form of vitamin D produced in the liver by hydroxylation of vitamin D 3 (cholecalciferol) by the enzyme vitamin D 25-hydroxylase. [3][4][5] Calcifediol can be further hydroxylated by the enzyme 25 (OH)D-1α-hydroxylase ...
CYP2R1 is cytochrome P450 2R1, an enzyme which is the principal vitamin D 25-hydroxylase. [5] [6] In humans it is encoded by the CYP2R1 gene located on chromosome 11p15.2. [7]It is expressed in the endoplasmic reticulum in liver, where it performs the first step in the activation of vitamin D by catalyzing the formation of 25-hydroxyvitamin D. [8]
proteins. 25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase[ 5 ] or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene. [ 6 ][ 7 ][ 8 ] VD 1A hydroxylase is located in the proximal tubule of the kidney and a ...
This process, known as hydroxylation, allows your body to use vitamin D for various vital processes. ... Healthcare professionals can diagnose vitamin D deficiency with a 25-hydroxy vitamin D ...
Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body. [1][7][2] One nanogram per millilitre (1 ng/mL) is equivalent to 2.5 nanomoles per litre (2.5 nmol/L). Severe deficiency: <12 ng/mL = <30 nmol/L[2] Deficiency ...
Vitamin D 5. sitocalciferol. (made from 7-dehydrositosterol) Several forms (vitamers) of vitamin D exist, with the two major forms being vitamin D 2 or ergocalciferol, and vitamin D 3 or cholecalciferol. [ 1 ] The term 'vitamin D' refers to either D 2 or D 3, or both, and is known collectively as calciferol.
The 1-hydroxy group is in the alpha position, and this may be specified in the name, for instance in the abbreviation 1α,25-(OH) 2 D 3. [6] Calcitriol is, strictly, the 1-hydroxylation product of calcifediol (25-OH vitamin D 3), derived from cholecalciferol (vitamin D 3), rather than the product of hydroxylations of ergocalciferol (vitamin D 2).
Vitamin D deficiency. Cholecalciferol is a form of vitamin D which is naturally synthesized in skin and functions as a pro-hormone, being converted to calcitriol. This is important for maintaining calcium levels and promoting bone health and development. [4] As a medication, cholecalciferol may be taken as a dietary supplement to prevent or to ...
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