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Late-life depression is often underdiagnosed, which is due to numerous reasons, including that depressed mood is commonly not as prominent as other somatic and psychotic symptoms such as loss of appetite, disruptions in sleep, lack of energy or anergia, fatigue, and loss of interest and enjoyment in normal life activities.
In their lifetime, 20% to 25% of women and 7% to 12% of men will have a major depressive episode. [35] The peak period of development is between the ages of 25 and 44. [3] The onset of major depressive episodes or MDD often occurs in people in their mid-20s and less often in those over 65.
Depression is common among those over 65 years of age and increases in frequency beyond this age. [31] The risk of depression increases in relation to the frailty of the individual. [285] Depression is one of the most important factors which negatively impact quality of life in adults, as well as the elderly. [31]
A review of studies revealed that irregular sleep, disrupted sleep and sleep disorders can affect function. The CDC (Centers for Disease Control and Prevention) recommends adults 65 and older get ...
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Psychomotor agitation is typically found in various mental disorders, especially in psychotic and mood disorders. It can be a result of drug intoxication or withdrawal. It can also be caused by severe hyponatremia. People with existing psychiatric disorders and men under the age of 40 are at a higher risk of developing psychomotor agitation. [2]
Fatal insomnia is an extremely rare neurodegenerative prion disease that results in trouble sleeping as its hallmark symptom. [2] The majority of cases are familial (fatal familial insomnia [FFI]), stemming from a mutation in the PRNP gene, with the remainder of cases occurring sporadically (sporadic fatal insomnia [sFI]).
One factor that could explain this change in sleep architecture is a disruption in the circadian rhythm, which regulates sleep. [19] This disruption can lead to sleep disturbances. [19] Some studies show that people with Alzheimer's disease have a delayed circadian rhythm, whereas in normal aging, an advanced circadian rhythm is present. [19] [20]
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