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Ototoxicity results in cochlear and/or vestibular dysfunction which can manifest as sensorineural hearing loss, tinnitus, hyperacusis, dizziness, vertigo, or imbalance. [6] [7] Presentation of symptoms vary in singularity, onset, severity and reversibility. [6]
Signs and symptoms of ototoxicity include tinnitus, hearing loss, dizziness and nausea and/or vomiting. [3] The diagnosis of medicine-induced ototoxicity is challenging as it usually shows only mild symptoms in early stages. Thus, prospective ototoxicity monitoring would be required when patients are using ototoxic medications. [1]
Sensory hearing loss often occurs as a consequence of damaged or deficient cochlear hair cells. [disputed – discuss] Hair cells may be abnormal at birth or damaged during the lifetime of an individual. There are both external causes of damage, including infection, and ototoxic drugs, as well as intrinsic causes, including genetic mutations.
The symptoms of cochlear hydrops fluctuate, and the condition may stabilize or go away on its own after several years. However, because the organ of Corti undergoes stress during the hydrops episodes, long-term hearing loss, tinnitus, or hyperacusis is possible. It is considered by some that cochlear hydrops is an early form of Meniere's disease.
Auditory neuropathy can be diagnosed with a battery of tests including otoacoustic emissions (OAE), auditory brainstem response (ABR), and acoustic reflexes. The classic AN paradigm would include present OAEs indicating normal outer hair cell function, absent or abnormal ABR with presence of the cochlear microphonic, and absent acoustic reflexes.
10-month-old Charlie, who has Usher syndrome, heard for the first time thanks to cochlear implants. / Credit: CBS Boston. For mom and dad, the procedure is life-changing. "To know she can hear and ...
For severe cases, cochlear implants may be considered. "Cochlear implants essentially replace the damaged hearing system with an electrode array for patients who do not benefit from hearing aids ...
The symptoms mentioned above are the external signs of the physiological response to cochlear overstimulation. Here are some elements of this response: Damaged sensory hairs (stereocilia) of the hair cells; damaged hair cells degenerate and die. In humans and other mammals, dead hair-cells are never replaced; the resulting hearing loss is ...
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