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Fundic gland polyposis is a medical syndrome where the fundus and the body of the stomach develop many fundic gland polyps. The condition has been described both in patients with familial adenomatous polyposis (FAP) and attenuated variants (AFAP), and in patients in whom it occurs sporadically.
Fundic gland polyps are found in 0.8 to 1.9% of patients who undergo esophagogastroduodenoscopy, and are more common in middle-aged women. [2] The risk of malignancy is very low or none, when sporadic. [3] Fundic gland polyposis is a medical syndrome with multiple fundic gland polyps.
Polyps are found throughout the GI tract (most frequently in the stomach and large intestine, followed by the small intestine) though typically avoid the esophagus. [6] A biopsy will reveal them to be hamartomas; the possibility that they progress to cancer is generally considered to be low, [7] although it has been reported multiple times in the past.
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Fundic gland polyposis is a medical syndrome where the fundus and the body of the stomach develop many fundic gland polyps. Pernicious anemia is caused when damaged parietal cells fail to produce the intrinsic factor necessary for the absorption of vitamin B12. This is the most common cause of vitamin B12 deficiency.
While colon polyps are not commonly associated with symptoms, occasionally they may cause rectal bleeding, and on rare occasions pain, diarrhea or constipation. [9] They are a concern because of the potential for colon cancer being present microscopically, and the risk of benign colon polyps becoming malignant over time. [ 10 ]
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The glands contains a number of cells, with the function of the glands changing depending on their position within the stomach. [citation needed] Within the body and fundus of the stomach lie the fundic glands. In general, these glands are lined by column-shaped cells that secrete a protective layer of mucus and bicarbonate.