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The hypothalamus uses follistatin to tell the pituitary to inhibit follicle-stimulating hormone; it also has many other systemic effects. Myocytes use myostatin to tell each other to inhibit myogenesis. Melanocyte-inhibiting factor (melanostatin) inhibits release of other neuropeptides such as alpha-MSH and also has many other functions.
Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene. [ 5 ] [ 6 ] HDAC6 has emerged as a highly promising candidate to selectively inhibit as a therapeutic strategy to combat several types of cancer and neurodegenerative disorders.
Histone deacetylase inhibitors may modulate the latency of some viruses, resulting in reactivation. [41] This has been shown to occur, for instance, with a latent human herpesvirus-6 infection. Histone deacetylase inhibitors have shown activity against certain Plasmodium species and stages which may indicate they have potential in malaria ...
ESAT-6 is one of the main proteins that is inhibited in the production of vaccines for M. tuberculosis [3] [6] with the combination of the increased antigenic factors agβ5-A and the agβ5-C. [6] There are studies that are currently trying to connect the linkage between ESAT-6 and the epithelial cells that are in the lungs, which has shown the ...
Allosteric regulation of an enzyme. In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the protein's activity, either enhancing or inhibiting its function.
Anti-interleukin-6 agents are a class of therapeutics. Interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. [ 1 ] Hence, anti-IL6 agents have been sought.
The most prominent example are serpins (serine protease inhibitors) which are produced by animals to protect against inappropriate enzyme activation and by plants to prevent predation. [6] Another class of inhibitor proteins is the ribonuclease inhibitors, which bind to ribonucleases in one of the tightest known protein–protein interactions. [7]
Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene. [5] [6] It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins. [7] The protein encoded by this gene is a member of the cyclin-dependent kinase, (CDK) family, which includes CDK4. [8]