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Hyperuricosuria is a medical term referring to the presence of excessive amounts of uric acid in the urine. For men this is at a rate greater than 800 mg/day, and for women, 750 mg/day. [1] Notable direct causes of hyperuricosuria are dissolution of uric acid crystals in the kidneys or urinary bladder, and hyperuricemia.
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [4] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. [1] High blood concentrations of uric acid can lead to gout and are associated with other medical conditions, including diabetes and the formation of ammonium acid urate kidney stones.
Pyruvic acid (CH 3 COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group. Pyruvate , the conjugate base , CH 3 COCOO − , is an intermediate in several metabolic pathways throughout the cell.
Urine pH varies with diet and a wide range of values occur in healthy subjects, although it is most commonly slightly acidic. Because the kidneys are involved in regulating acid-base balance, the urine is typically acidic in people with metabolic or respiratory acidosis and alkaline in those with alkalosis.
The signs and symptoms of abnormal urine color are shown as follows: Unexplained urine color other than straw-yellow has continued for a long time. [1] Once observe blood in urine. [1] Clear, dark-brown urine. [1] Risk factors of clinical abnormal urine color include elderly age, strenuous exercise, and family history of related diagnosis. [2]
A urine test is any medical test performed on a urine specimen. The analysis of urine is a valuable diagnostic tool because its composition reflects the functioning of many body systems, particularly the kidneys and urinary system, and specimens are easy to obtain. [1]
The children, he concluded, had excess phenylpyruvic acid in the urine, the condition which came to be called phenylketonuria (PKU). [ 19 ] His analysis of the urine of the two affected siblings led him to request many physicians near Oslo to test the urine of other affected patients.