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Referring to a common salt of fluoride, sodium fluoride (NaF), the lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride/kg body weight). [ 2 ] [ 3 ] [ 4 ] Ingestion of fluoride can produce gastrointestinal discomfort at doses at least 15 to 20 times lower (0.2–0.3 mg/kg or 10 to 15 ...
Rare but serious allergic reactions are possible; symptoms include itching, swelling, and difficulty breathing. Certain formulations of stannous fluoride in dental products may cause mild tooth discoloration; this is not permanent and can be removed by brushing, or can be prevented by using a stabilised stannous fluoride toothpaste. [15] [16] [34]
Topical fluorides are fluoride-containing drugs indicated in prevention and treatment of dental caries, particularly in children's primary dentitions. [1] The dental-protecting property of topical fluoride can be attributed to multiple mechanisms of action, including the promotion of remineralization of decalcified enamel, the inhibition of the cariogenic microbial metabolism in dental plaque ...
Elevated prenatal exposure to fluoride was associated with increased risk of neurobehavioral problems in 3-year-olds, according to a study of children in Los Angeles.
Fluoride or fluorine deficiency is a disorder which may cause increased dental caries [1] and possibly osteoporosis, [2] [3] due to a lack of fluoride in diet. [4] [5] Common dietary sources of fluoride include tea, grape juice, wine, raisins, some seafood, coffee, and tap water that has been fluoridated. [6]
Scientists have developed a new toothpaste that shows potential to prevent severe allergic reactions in adults with peanut allergies. An early-stage clinical trial tested whether 32 adults with ...
By Jonathan Stempel (Reuters) -Procter & Gamble and Colgate-Palmolive are among the defendants in six new lawsuits targeting the sale of toothpaste and mouth rinse for young children because the ...
Dental fluorosis is caused by a higher than normal amount of fluoride ingestion whilst teeth are forming. Primary dentine fluorosis and enamel fluorosis can only happen during tooth formation, so fluoride exposure occurs in childhood. Enamel fluorosis has a white opaque appearance which is due to the surface of the enamel being hypomineralised ...