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Dieldrin is an organochlorine compound originally produced in 1948 by J. Hyman & Co, Denver, as an insecticide. Dieldrin is closely related to aldrin , which reacts further to form dieldrin. Aldrin is not toxic to insects; it is oxidized in the insect to form dieldrin which is the active compound.
DDT and DDE are resistant to metabolism; in humans, their half-lives are 6 and up to 10 years, respectively. In the United States, these chemicals were detected in almost all human blood samples tested by the Centers for Disease Control in 2005, though their levels have sharply declined since most uses were banned. [84]
DDT can be detected in foods from all over the world and food-borne DDT remains the greatest source of human exposure. Short-term acute effects of DDT on humans are limited, however long-term exposure has been associated with chronic health effects including increased risk of cancer and diabetes, reduced reproductive success, and neurological ...
Other members of the cyclodiene family of organochlorine insecticides are aldrin and its epoxide, dieldrin, as well as endrin, which is a stereoisomer of dieldrin. Cyclodiene derives its name from hexachlorocyclopentadiene, a precursor in its production. Synthesis of cis- (above) and trans-chlordane (below)
The organochlorine pesticides, like DDT, aldrin, and dieldrin, are extremely persistent and accumulate in fatty tissue. Through the process of bioaccumulation (lower amounts in the environment get magnified sequentially up the food chain), large amounts of organochlorines can accumulate in top species like humans.
The metabolism of oral aldrin exposure has not been studied in humans. However, animal studies are able to provide an extensive overview of the metabolism of aldrin. This data can be related to humans. Biotransformation of aldrin starts with epoxidation of aldrin by mixed-function oxidases , [15] which forms dieldrin. This conversion happens ...
The FDA’s recent ban on Red Dye No. 3, set to take effect by 2027 for foods and 2028 for drugs, marks a significant step in addressing safety concerns over artificial food dyes in the U.S. food ...
The overarching theme of Silent Spring is the powerful—and often negative—effect humans have on the natural world. [26] Carson's main argument is that pesticides have detrimental effects on the environment; she says these are more properly termed " biocides " because their effects are rarely limited to solely targeting pests.