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Beyond identifying and discontinuing the offending drug, individuals with mild symptoms may require no further treatment. Those troubled by more significant symptoms such as itching or fever may require antihistamines, topical corticosteroids, systemic corticosteroids, and/or antipyretics. Individuals with liver, lung, kidney, and/or severe ...
Drug reactions have been reported to cause 80–95% of TEN cases. [6] The drugs most often implicated in TEN are: antibiotics sulfonamides (sulfamethoxazole, sulfadiazine, sulfapyridine) beta-lactams (cephalosporins, penicillins, carbapenems) nonsteroidal anti-inflammatory drugs; allopurinol; antimetabolites (methotrexate) antiretroviral drugs ...
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...
The most common symptom of lymphocytic esophagitis is dysphagia, or difficulty swallowing, prevalent in 53 to 57% of individuals with the condition [1] [2] due to inflammation, narrowing or altered movement of the esophagus. Other symptoms include heartburn, abdominal pain, nausea and food bolus obstruction.
However, the symptoms of chest pain and trouble swallowing may be severe enough to require treatment with medications, and rarely, surgery. The initial step of treatment focuses on reducing risk factors. While weight reduction may be useful in reducing symptoms, the role of acid suppression therapy to reduce esophageal reflux is still uncertain ...
Dysphagia is distinguished from other symptoms including odynophagia, which is defined as painful swallowing, [8] and globus, which is the sensation of a lump in the throat. A person can have dysphagia without odynophagia (dysfunction without pain), odynophagia without dysphagia (pain without dysfunction) or both together.
The clinical examination and patient history should look for alarm symptoms. Alarm symptoms include dysphagia , especially if progressive, or odynophagia , overt gastrointestinal bleeding , such as melena or hematemesis , persistent vomiting , unintentional weight loss , family history of gastric or esophageal cancer , palpable abdominal or ...
Substance use disorder (SUD) is the persistent use of drugs despite substantial harm and adverse consequences to self and others. [8] Related terms include substance use problems [9] and problematic drug or alcohol use. [10] [11] Substance use disorders vary with regard to the average age of onset. [12]