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As of 2013, an estimated 75% of 700 million dogs worldwide were free to roam and reproduce, resulting in overpopulation, high mortality rates and poor health. [1] The main management approach is surgical sterilization, i.e. the removal of testes or ovaries, often performed through trap-neuter-return strategies. [2]
Estriol (E3), sold under the brand name Ovestin among others, is an estrogen medication and naturally occurring steroid hormone which is used in menopausal hormone therapy. [12] [4] [6] [13] It is also used in veterinary medicine as Incurin to treat urinary incontinence due to estrogen deficiency in dogs.
Aqueous suspension for intramuscular injection: Depo-Provera – 150 mg/mL (for contraception), 400 mg/mL (for cancer) Aqueous suspension for subcutaneous injection: Depo-SubQ Provera 104 – 104 mg/0.65 mL (for contraception) It is also available in combination with an estrogen in the following formulations:
By intramuscular injection, the elimination half-life of E2-EN has been found to be 5.6 to 7.5 days, while the half-life of algestone acetophenide and its metabolites has been found to be 24 days. [16] [17] [18] [2] Following a single injection, E2-EN and DHPA are detectable in the circulation for up to 30 to 60 days. [19] [2]
Atypical (dual estrogen and nitrogen mustard alkylating antineoplastic): Estramustine phosphate sodium (Emcyt) – 140 mg; Oral estradiol valerate (except in combination with dienogest as an oral contraceptive) is not available in the U.S. and is used primarily in Europe. [2]
EB is an estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like endogenous estradiol. [20] It is an estradiol ester and prodrug of estradiol with a longer duration of action than estradiol when administered by intramuscular injection in oil solution or aqueous suspension. [20]
How hormones for phallic growth work depend on the age of the patient and the severity of the problem. Children may receive weekly hormone injections to correct the problem, while babies may ...
In transgender women, estradiol valerate given by intramuscular injection is usually used at a dosage of 5 to 20 mg, but up to 30 to 40 mg, once every 2 weeks. [30] [31] [29] Estradiol valerate has also been used at a dose of 10 to 40 mg by intramuscular injection to limit bleeding in women with hemorrhage due to dysfunctional uterine bleeding.
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