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This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague Dawley Animal Company) in Madison, Wisconsin, in 1925. The name was originally hyphenated, although the brand styling today (Sprague Dawley, the trademark used by Inotiv) is not. The average litter size of the Sprague Dawley rat is 11.0. [29]
Harlan Sprague Dawley Inc. was a supplier of animals and other services to laboratories for the purpose of animal testing. [1] It provided pre-clinical research tools and services for the pharmaceutical , biotechnology , agrochemicals , industrial chemical, and food industries.
The reference strain to best illustrate the ADHD-like deficits of the SHR is the Sprague-Dawley. Although some argue that the deficits are only present because the Sprague-Dawley is naturally less active anyway. [citation needed]
The company began offering rats in 1969, including Sprague Dawley, one of the most popular breeds of laboratory rats. That same year, Taconic became the first breeder to receive full accreditation from the American Association for the Accreditation of Laboratory Animals. [citation needed]
Another body type variation that has risen to prominence more recently in the hobby is the Dwarf rat. Dwarfism arose as a mutation among Sprague-Dawley rats kept for research in the 1970s. [26] Adult dwarfs are considerably smaller than their standard counterparts, with males between 100 and 130g as opposed to 300g or more.
Sprague-Dawley rats have a lifespan of about two years and have a high risk of cancer over their lifespan (one study concluded that over eighty percent of males and over seventy percent of females developed cancer under normal conditions). [40] [41] [42] The Séralini experiment covered the normal lifespan of these rats. The longer an ...
Mar. 10—Despite years of debate, land disputes and ballot measures, Sprague Avenue in Spokane Valley has remained relatively the same for decades. The thoroughfare last saw a transformative ...
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